Sotnikova Tatiana Nikolaevna
City clinical I.V. Davydovsky Hospital, Russian FederationTitle: Prognostic significance of PD-L1 expression as a potential predictor of survival in gastric cancer
Abstract
Currently, the effect of PD-L1
expression on the prognosis in patients with malignant neoplasms of various localizations
is being actively studied, however, data remains unclear, due to differences in
approaches and methodology of PD-L1 testing and scoring, as well as other
determinants. For instant, recent research shows that the PD-L1 22C3 pharmDx
assay might be used as a companion diagnostic assay for the use of
pembrolizumab in patients with advanced gastric cancer, moreover the 22C3
expression correlates with the tumor response. However, studies that report the
expression of PD-L1 detected by clones SP142 and SP263 (for the atezolizumab
and durvalumab, respectively) are rare. The prognostic role of PD-L1 expression
in patients who were not treated with immune checkpoint inhibitors has also not
been investigated.
Biography
September 2003 – July 2009, Russian
National Research Medical University (RNRMU). Postgraduate studies –
internships and residency as pathologist at RNRMU. Currently, Head of the
department – specialist (pathologist) in City clinical Hospital named after
I.V. Davydovskiy, Moscow, Russia. Scientific interest and research in oncology
of the gastrointestinal tract and tumors of the pancreatobiliary zone.
Dissertation for an applicant for a scientific degree Candidate of Medical
Sciences.
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