Priyadharshini
Saveetha Dental College & Hospitals, IndiaTitle: Preliminary Investigation of Correlation between miRNA10a and Glucose Transporters in Oral Squamous Cell Carcinoma with Diabetes
Abstract
Introduction: MicroRNAs (miRNAs) are well-established post-translational non-coding RNAs that play crucial roles in mRNA degradation and repression. Glucose transporter 1 (GLUT1) showed correlation along with various miRNA, specifically miRNA10a expression in lung cancers. The role of miRNA10a along with glucose upregulation leading to cancer proliferation in oral squamous cell carcinoma (OSCC) is unknown. This study aimed to investigate the expression levels of miRNA10a and GLUT1 in OSCC patients with diabetes.
Materials and methods: miRNA10a and GLUT1 expression were estimated in OSCC, precancerous, and healthy tissues using quantitative reverse transcriptase polymerase chain reaction (RT-PCR). miRNA10a and GLUT1 expression levels were recorded as fold change. Further, a one-way analysis of variance (ANOVA) test was performed to find whether there is any difference in miRNA10a and GLUT1 expression between OSCC, precancerous, and healthy tissues.
Results: The RT-PCR findings revealed an increased expression of miRNA10a and GLUT1 in OSCC compared to precancerous and healthy tissue. There is a positive correlation between miRNA10a and GLUT1 expression levels in both potentially malignant and control tissues, with a marked increase in cancerous tissue. This study demonstrated the significance of upregulated miRNA10a expression, indicating a direct correlation with OSCC proliferation via GLUT1 overexpression. Specifically, miRNA10a exhibited a fold change of 1.2±0.072 in potentially malignant tissue and 1.4±0.05 in cancer tissue, while GLUT1 exhibited a fold change of 1.25±0.092 in potentially malignant tissue and 0.092±0.08 in cancer tissue, respectively.
Conclusion: This research highlights the role of miRNA10a in cancer progression by facilitating proliferation through the regulation of GLUT1 in cancerous tissues, particularly in hyperglycemic conditions. This mechanism further contributes to increased glucose transport in cancer patients, which may potentially impede tumor prognosis. These findings underscore the potential significance of targeting miRNA10a and GLUT1 as therapeutic interventions in cancer management.
Biography
Priyadharshini R is an assistant professor in the pathology department at Saveetha Dental College and Hospitals (Saveetha University). Her specialty in oral pathology was oral and maxillofacial pathology-based diagnosis. She earned her BDS from Dr. MGR University in Chennai in 2014 and her MDS in Oral Pathology from A.J. Institute of Medical Sciences & Research Centre in Mangalore, which are associated with Rajiv Gandhi University of Health Sciences in Bangalore. She works as an assistant professor and has three years of teaching expertise. Her areas of focus in research are molecular biology and oral cancer. She had over 95 publications that has been cited for more than 60times and her publication has h-index of 4.
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