Maria Tikhonovskaya

N.N.Blokhin NMRCO, Russian Federation

Title: Sentinel lymph node detection in early stage ovarian cancer: the primary experience in N.N. Blokhin National Medical Research Center of Oncology

Abstract

Background. Surgical staging including pelvic and para-aortic lymphadenectomy is recommended in patients with clinical early-stage epithelial ovarian cancer. The therapeutic role of pelvic and para-aortic lymphadenectomy is still under debate, this procedure can increase risk of intra- and post-operative complications. Using the sentinel lymph node (SLN) detection in early stage ovarian cancer in very promising and decreases the level of surgical damage. But nowadays the data on effectiveness, safety sensitivity and specificity of SLN are limited and the technique has to be standardized.

Aim. To determine the feasibility of the SLN detection procedure using indocyanine green in early stage ovarian cancer.

Materials and methods. Twenty three patients underwent SLN detection using indocyanine green: 13 patients with clinical stage I epithelial ovarian cancer and 10 patients with suspicious tumors of the ovary. The tracer was injected into hilum of the ovary, or ovarian ligaments, or ovarian ligament stumps in the case of previous adnexectomy. SLN were detected in infrared spectrum. Systemic retroperitoneal lymph node dissection of the pelvic and paraaortic areas was performed after SLN being removed. Frozen section of was not performed in this study. The special device was constructed to prevent the extra tissue diffusion of the tracer in abdominal cavity.

Results. SLN were detected in 18 (78,1%) patients. In 11 patients SLN node was detected in paraaortic area, in 6 patients - in paraaortic and pelvic area, in 1 patient - only in pelvic area. No one of patients had metastatic disease. The use of special device had demonstrated prevention of extra tissue tracer diffusion and improved the feasibility of SLN detection in laparoscopy and open surgery.

Conclusion. The primary experience demonstrates SLN mapping of the ovary being feasible. Using special device for tracer injection improves SLN detection. Prospective study is required to evaluate sensitivity and specificity of SLN detection in early stage ovarian cancer.

Biography

Maria Tikhonovskaya has completed his PHD at the age of 30 years from N.N. Blokhin Russian Oncology Reseach Center, Russian Federation. She is the scientific researcher of the Oncogynecological Department of N.N. Blokhin National Medical Research Center of Oncology. She has over 10 publications, and her publication h-index is 3.

4th International Conference on Oncology and Research Treatment

Maria Tikhonovskaya

Title: Sentinel lymph node detection in early stage ovarian cancer: the primary experience in N.N. Blokhin National Medical Research Center of Oncology

Abstract

Biography

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