Jeslin

Sree Balaji Medical College and Research, India

Title: Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment

Abstract

Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen- activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases. Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling pathways to investigate potential new anticancer small molecules. Furthermore, clinical trials with indole alkaloids in cancer treatment are also highlighted.

Biography

Jeslin is Associate Professor, Department of Pharmaceutics, Faculty of Pharmacy, Sree Balaji Medical College and Hospital Campus, Bharath Institute of Higher Education and Research, Chennai, Tamilnadu, India. She pursuing PhD in Faculty of Pharmacy, Sree Balaji Medical College and Hospital Campus, Bharath Institute of Higher Education and Research, Having 13 years of experience in various fields in Academics and Scientific Research and Development. During this time, she published 10 text books. She has guided many B.Pharm students at research level. She published Research papers both at national and international. She has 3 U.K. patent grant, 7 Indian Design Patent grants, 5 Indian published patents. She is member of many scientific associations, and expertise of research in Novel Drug Delivery. He received Awards and Honours and participated 25+ Conferences and 15 FDPs and completed 5+ additional/skill courses through online platforms. Received Best Faculty Award for 2021 – 2022, and Best Academic Award 2023. As a result of these academic achievements and experience, it is expected that will fill the need of pharma profession.

4th International Conference on Oncology and Research Treatment

Jeslin

Title: Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment

Abstract

Biography

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