Basma Ezzat Mustafa Al Ahmad
International Islamic University, MalaysiaTitle: Effect of Flaxseed on Genes Expression during Wound Healing in Animal Model
Abstract
BACKGROUND: Wound healing is a natural restorative response to tissue injury, and it involves regulated order of cellular and biochemical actions to reinstate tissue after injury, which involves resurfacing reconstitution, and restoration of tensile strength of injured skin. Normal and impaired wound healing post-significant problems related to healthcare and expenditure. Most of the chemical medications which widely used for wound healing might cause unwanted side effects with prolonged use such as hyper scarring, thus studies using natural products are now deemed important. Flaxseed is a natural product that enhances the immune system functioning against different diseases. Nevertheless, limited studies have been done looking into the response triggered by immune cells and the wound-healing-related genes with the use of flaxseed extract onto the wounded skin for the healing process.
AIM: The main objective of this study is to analyze the expression of wound healing-related genes during different stages of the wound healing process induced by flaxseed in vivo.
METHODS: The effect of flaxseed oil in the early stages (day 4 and 7) and late stages (day 14) of wound healing was explored on New Zealand white rabbits by creating a longitudinal full thickness wound on their back. The gene expression profiles of transforming growth factor-beta (TGF-?), IL-6, and metalloproteinase (MMP9) genes which have roles in wound healing through inflammation, proliferation, and remodeling were studied by polymerase chain reaction method. RESULTS: Flaxseed extract has significant effects in up-regulating anti-inflammatory marker TGF-? _in wounds. Flaxseed oil also reduces the expression level of MMP9 on day 14 of wound healing.
CONCLUSIONS: This suggests that flaxseed extract has the potential to promote wound healing through the regulation of TGF-? _and MMP9 in vivo
Biography
Basma has Ph.D. in Clinical Pharmacology, Master’s in advanced clinical Laboratory Sciences and bachelor’s in pharmacy from the University of Baghdad, Iraq. She started her career in Kulliyyah of Dentistry, International Islamic University Malaysia in 2008. She was the Head of research. Currently, she is the Head of the Fundamental Dental Medical Sciences Department, an Editor member of the IIUM Journal of Orofacial and Health Sciences, a Program Coordinator for the Doctor of Philosophy in Dental Sciences, and an Executive Committee member of the Malaysian Society of Oral Microbiologists and Oral Immunologists. Her research interests are in the fields of pharmacology, endocrinology, microbiology, and natural products. She has massive research experience conducting in vitro and in vivo anti-inflammatory, anti-bacterial, and wound healing effects of different natural products.in addition to the identification of different tumor markers for early diagnosis of different types of cancer. She has achieved several grants nationally and internationally, during this period, she manages to publish 5 books, and 52 publications.
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