Rationale: Lipomatosis is an autosomal dominant condition in which multiple lipomas are present in the body. It is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. A hypertensive crisis is a remarkable lethal sequence of hypertension. Patient concerns: A middle-aged furniture worker married heavy smoker male, Egyptian patient was presented to the physician outpatient clinic (POC) with angina, a hypertensive crisis with associated lipomatosis. Diagnosis: Lipomatosis with hypertensive emergency and angina in suspected Dercum’s disease. Interventions: Electrocardiography, echocardiography, and oxygenation. Outcomes: Good responses for both angina and hypertensive emergencies despite the presence of numerous remarkable risk factors were the results. Lessons: The association of hypertensive emergency and angina in a heavy-smoker middle-aged male patient with lipomatosis and suspected Dercum’s disease is a highly interesting new association in the current case study. Not all patient thinks such as think that eating adulterated honeybees and its relation to induce hypertensive emergency and angina are considered. It may be a doubt.